The doctor opens the game on Frederik’s diagnosis, killed at the age of 22

The prince FrederikFrom Luxembourg, he died at the beginning of this month, at the age of 22, after a long battle against a disease. Prince’s heir Robert and the princess Julie de Nassau, The young man died due to the complication of Polg, a genetic mitochondrial disorder whose diagnosis received at 14.

But what does Polg cause in the patient? The pediatric geneticist WILLE NORAT SIQUEIRA He said the disease “strikes the organs more acute”.

“The disorders related to the variants of the Polg gene, a genetic mitochondrnopathy considered neurodegenerative, include a large clinical picture. The genetic mitochondrial disorder steals the energy of body cells and causes progressive multiple organs, such as brain, nerves, nerves, liver, intestines, muscles, demolition functions and glasses”, “,” I told the boys.

And complete: “The disorder leaves the cells of the body without energy, which is vital for the functioning of the body. From this there is the dysfunction and the progressive failure of several organs.”

But how is the diagnosis made?

“Establishing diagnosis depends on clinical results such as muscle weakness and convulsions, for example, and the presence of two pathogenic variants of the Polg gene in the individual with symptoms through genetic sequencing “.

Finally, it underlines: “Symptoms can start both in childhood and adults. People with early debut disease (before 12 years) have a worse prognosis. In late form, in young people and adults, the course of symptoms is lighter, a better prognosis. The symptoms more acutely influence the organs most dependent on energy such as the central nervous system, the liver e

It is interesting to note that there is no cure for Polg, that is, the treatment is only palliative, aiming for an improvement in the quality of life.

Source: Terra