Nobel Medicine Awards scientists who have exploited research against cancer and autoimmune diseases

Graduates – two American and one Japanese researchers – receive gold medal, diploma and the equivalent of about $ 6.2 million

The Nobel Prize in Medicine 2025 was granted For three scientists who study peripheral immune tolerance -americans Mary Brukow, Fred Ramsdell and the Japanese Shimon Sakaguchi, announced the Swedish Academy of Sciences this Monday 6.

The system Immunological is crucial for our survival and our health. Without it, we would be highly vulnerable, since we are constantly exposed to microbes, for example. Through this system, the body fights pathogens and maintains a type of memory to find out what is the best way to react to this problem.

Peripheral immune tolerance is one of the ways in which the body uses to prevent the immune system of deregiamente and attack its tissues rather than fight strange invading.

The results of this trio of researchers guide the development of medical treatments for cancer and autoimmune diseases. In addition, it can help lead safer transplants.

In the mid -90s, Sakaguchi of the University of Kyoto discovered a class of cells beyond the central system, which explains how the body protects itself from autoimmune diseases.

Mary Brukow and Fred Ramsdell – respectively of the universities of Princeton and California – made another crucial discovery in 2001, when they presented the explanation of the particular vulnerability of a specific strain of mice in autoimmune diseases.

They discovered that the mice had a mutation in a gene that called Foxp3. They also showed that the mutations in the human equivalent of this gene cause a serious autoimmune disease, the Ipex.

Two years later, Sakaguchi connected these scientific results, showing that the gene Foxp3 Check the development of the cells it had identified in 1995. These cells – now call T -cell adjustment – They monitor other immune cells and ensure that our immune system does not attack the tissues of our body.

With the understanding of this mechanism, it is possible:

• Prevent cells from the protective walls of tumors, which compromise the treatment against some types of cancer
• Promote the formation of multiple T cells, which is useful in the treatment of autoimmune diseases
• Act so that the T cells do not act in the refusal of a transplant organ, such as a kidney or a liver

The winner (or winners) will receive a gold medal, a diploma and 11 million Swedish crowns (the equivalent of approximately 6.2 million dollars).

Last year, the Medical Award was the Victor Ambros and Gary Ruvkun of the Americans for the discovery of micro -torna molecules and their role in activating and deactivating DNA extensions.

The program follows:

• Tuesday, 7: Physics
• Wednesday, the eighth: chemistry
• Thursday, 9,: Literature
• Friday, 10: peace
• Monday 13: economics

The delivery ceremony of the prize is scheduled for December 10, as occurs every year, the anniversary of the death of the Swedish chemist Alfred Nobel (1833-1896), creator of the prize.

Created in 1901, the prize was awarded 627 times to 976 people and 28 organizations. Brazil has never received a Nobel Prize, although some names have already thought about betting lists.

Source: Terra

Ben

Ben Stock is a lifestyle journalist and author at Gossipify. He writes about topics such as health, wellness, travel, food and home decor. He provides practical advice and inspiration to improve well-being, keeps readers up to date with latest lifestyle news and trends, known for his engaging writing style, in-depth analysis and unique perspectives.