The film won Demi Moore the Golden Globe for Best Actress (Comedy/Musical)
The Substance should not get a sequel or prequel, confirmed the director Coralie Fargeat.
During the Palm Springs International Film Festivalthe filmmaker was asked by Variety about the possibility of the feature film gaining new developments, to which Fargeat responded (via NME):
No, the point of this film is to introduce new things to the world. Like, no sequels, no preludes, no number two [ou] number three. So I’ll still be happy to bring something new to the world soon.
#TheSubstance Director Coralie Fargeat says there will not be a sequel to the film. #PSIFFhttps://t.co/Zb60FtL8TQpic.twitter.com/JSD6AZ6Pnu
—Variety (@Variety) January 4, 2025
Golden Globe
The Substance was nominated to Golden Globe for Best Film (Comedy/Musical), Best Supporting Actress, Best Director, Best Screenplay and Best Actress (Comedy/Musical). The MUBI film only secured the award for Best Actress (Comedy/Musical), received by Demi Moore.
Demi Moore is taking home the award for Best Female Actor – Motion Picture – Musical/Comedy for The Substance. Congratulations! 🎉 #GoldenGlobespic.twitter.com/cUXNNSmX7O
— Golden Globes (@goldenglobes) January 6, 2025
On The Substance
In the film directed by Coralie Fargeat, Demi Moore plays Elisabeth Sparkle, a former celebrity past her prime who is suddenly fired from her television show by the repulsive studio boss, Harvey (Dennis Quaid).
She is then drawn to the opportunity presented by a mysterious new drug: THE SUBSTANCE. All it takes is one injection and she is reborn—temporarily—as the stunning Sue, a young woman in her early twenties (Margaret Qualley).
See this photo on InstagramA post shared by MUBI BRASIL (@mubibrasil)
The only rule? The time needs to be divided: exactly a week in one body, then a week in the other. No exceptions. A perfect balance. What could go wrong?
Source: Rollingstone

Rose James is a Gossipify movie and series reviewer known for her in-depth analysis and unique perspective on the latest releases. With a background in film studies, she provides engaging and informative reviews, and keeps readers up to date with industry trends and emerging talents.