Brazil will have the first national pens for the treatment of diabetes and obesity from August

Brazil will have the first national pens for the treatment of diabetes and obesity from August


Liraglutide medicines should cost up to 20% less than the reference options

The pharmacist EMS It provides the launch in August the first Brazilian versions of Penne for the treatment of type 2 diabetes and obesity. With production authorized by National Health Surveillance Agency (Anvisa) Last year, the company says that national drugs should cost between 10% and 20% less than current reference brands.

Two products will be launched: Olire, focused on the control of the obesityand lux, Suitable for the treatment of diabetes Type 2 New Nordisk.

The substance acts similar to semaglutado, present in Ozempic and in its version for the treatment of obesity, the Wegovyalso by the Danish company. These active ingredients imitate the action of the GLP-1 intestinal hormone, reporting brain satiety and regulating glucose levels.

According to EMS, the production will be 100% Brazilian and aims to compete with the international market. The forecast is to produce 200 thousand pens (between Olire and Lirux) in the first months of launch, still in 2025. In a year more than 500 thousand units should be available.

The company is also preparing for the launch of its version of trafficlutados in 2026, when the drug patent will expire in Brazil. The drugs began to be manufactured in a pilot phase last year at the new pharmaceutical factory in Hortolândia (SP). The unit was for the first time in the country for the local production of liraglutide and semaglutado molecules.

How they work

THE liraglutide “Imitates” the LPG-1, a hormone produced by the intestine and released in the presence of glucose, reporting to the brain that we are fed. In this way, it makes the appetite laugh by increasing the insulin levels, balancing the amount of blood sugar.

Medicines based on this substance are of daily use. Lirux will have a dose of 1.8 mg and can be used by adult patients, teenagers and children over 10 years old with type 2 diabetes.

The dose of oil will be up to 3 mg and the drug will be intended for 12 -year adults and teenagers with obesity or adults with overweight and comorbidity such as diabetesdyslipidemia e hypertension.

In clinical studies, liraglutide has produced an average weight loss of 4 to 6 kg, with part of the patients who reached 5% and 10% of the reduction in body weight. The substance is also associated with improvements in cardiovascular risk markers.

What is the difference between liraglutide and semaglutide?

Both drugs are similar hormonal similar, therefore they have a very similar mechanism of action. The main differences between them seem to be the duration of the effect and power.

The semaglutido has a longer duration of the action and is usually administered once a week, while the liraglutide must be injected every day. Also, against the weight loss of 10% of the last, the The traffic semaglutado can lead to a loss of 15% to 17%.

Second analysesThe semaglutado was also associated with reductions in food desires, which is less evident with the liraglutide, suggesting different mechanisms for regulating food intake.

Source: Terra

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