Medical Nobel: the winners revolutionize cancer treatments and autoimmune diseases

Mary E. Britkow, Fred Ramsdell and Shimon Sakaguchi received the prize for their discoveries on the immune system

This Monday, the Americans Mary E. BRUNKOW AND Fred Ramsdell And the Japanese Shimon Sakaguchi have been announced as winners of Nobel Prize for Physiology or Medicine of 2025. Scientists have developed research on the immune system, which can revolutionize cancer treatments and fight other diseases.

“His discoveries have been decisive for our understanding of how immunity works and because not everyone develops serious autoimmune diseases”, declared Olle KämpiPresident of Nobel Committeein a press release.

Understand the discoveries of the Nobel winners

Shimon Sakaguchi has opened the doors for the best understanding of the immune system. In 1995, he discovered that central tolerance, responsible for the elimination of cells harmful to health, was not the only one able to protect the body from autoimmune diseases. This is because, with their research, scientists have detected the presence of regulators, a new type that acts by preventing the body from attacking their tissues.

Later, in 2001, Mary Brukow AND Fred Ramsdell contacted, when analyzing a mutation in the gene Foxp3, That this genetic unit helps in the development of recent discoveries. Therefore, two years later, Sakaguchi connected his studies and released the importance of peripheral immune tolerance.

This process, as the researchers point out, regulates the excessive reactions of the body in the face of the invasion of harmful agents. Therefore, it allows the system not only to protect the body of the action of these components, but prevents it from damaging healthy areas.

Research innovates treatments

The results have stimulated other studies, which are being tested, able to revolutionize cancer treatments and autoimmune diseases. Scientists try to understand how regulatory T cells can fight type 1 diabetes, lupus and multiple sclerosis.

In addition, they analyze the ways to inhibit their action in tumors. This is because there is evidence that some tumors are associated with these cells as a strategy to escape the immune system. Another possible performance of the new agents is to increase tolerance to a transplanted organ. According to the Nobel Committee, the winners “They launched the foundations for the development of therapies that can benefit from millions of people.”

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Source: Terra

Ben

Ben Stock is a lifestyle journalist and author at Gossipify. He writes about topics such as health, wellness, travel, food and home decor. He provides practical advice and inspiration to improve well-being, keeps readers up to date with latest lifestyle news and trends, known for his engaging writing style, in-depth analysis and unique perspectives.