According to a study in the journal Cell Metabolism, estrogen-related gut bacteria may be responsible for premenopausal depression.
According to a study published in the scientific journal cellular metabolism, Estrogen-related gut bacteria may be responsible for premenopausal depression. The idea is that the discovery will help develop future therapies targeting this microbe to treat the disease.
- People with severe depression have missed out on treatment during the pandemic
- A family history of depression increases the chances of developing the disease.
To arrive at this finding, the researchers measured estradiol levels in the blood samples of 189 premenopausal women, 91 of whom had been diagnosed with depression. The results revealed that, on average, estradiol levels were nearly 43 percent lower among participants with the disease.
The team also extracted gut microbes from participants’ fecal samples and mixed them into a solution with estradiol. In practice, it was possible to notice that the intestinal bacteria of participants with depression break down estradiol more quickly. This suggests that differences in the gut microbiome contribute to reduced estradiol levels in depression.
The team identified an estradiol-degrading microbe called Klebsiella aerogenes, which was 14 times more prevalent in stool samples from participants with depression.
Gut bacteria cause depression
Earlier this year, a study published in the journal Nature communications pointed out that the Gut bacteria may play a role in depression. The researchers found that different types of bacteria increased or decreased markedly in people with depressive symptoms. This reinforces the idea that how a person feels is closely related to what they consume.
As early as 2022, an article suggested it people with intestinal disease are more susceptible to depression. The team of scientists found a two-way link between chronic bowel disease and depression (that is, people with one condition were more likely to develop the other).
Source: New scientist
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