The study identifies the protein responsible for aging

The study identifies the protein responsible for aging

Gray hair, wrinkles, gradual decline – the AP2A1 protein can be responsible for all this. Could this discovery prolong life in the future and improve the treatment of age -related diseases? “Everything passes, everything will pass,” says a song immortalized by the singer Nelson Ned. People inevitably age. This is the reason why humanity has long sought youth sources, elders or anti -overwhelming products that promise young eternal young people.

Now Japan researchers have discovered a protein that would be responsible for the aging process. If it is blocked, cellular aging can be delayed or even reversed.

Not only could people live longer, but also age -related diseases such as osteoporosis, heart disease, some tumors and neurodegenerative diseases could be reduced to a minimum. Some diseases may be prevented before the first symptoms appeared.

The AP2A1 protein makes cells larger and more inactive

During the aging process, the cells gradually become more inactive. They are no longer divided, but they don’t even die. This condition is known as senescence or cellular aging.

Senescent cells are not only old but also significantly larger. This is probably due to the proteins that thicken the so -called stress fibers on cell walls, making them more immobile.

“An intriguing clue is that the stress fibers in senescent cells are much thicker than young cells, suggesting that the proteins of these fibers help to maintain their size,” says Pirawan Chantachotikul of the University of Osaka, one of the authors of the study, published in the scientific mobile reporting magazine.

In the study, the researchers focused on the AP2A1 protein, which is mainly found in senescent cells. To test the hypothesis that the protein had a key document in aging, the researchers modulated the expression of AP2A1 in young and old cells.

“The suppression of AP2A1 in older cells reversed senescence and promoted the renewal of the cells, while the overexpression of AP2A1 in the young cells accelerated senescence,” says Shinji Deguchi, another author of the study.

It will surely take time until the results find a practical application. But unlike many anti -aging products, they could actually contribute to a longer life and better health, treating not only the typical symptoms of aging but also the cellular causes of the process.

Source: Terra

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