Studio compared the performance of patients with progressive primary aphasia and healthy individuals, identifying tasks that can report the presence of the syndrome
The difficulty of finding the words or customs to exchange them for others semantically like – such as the knife and the cutter – or phonologically – such as the knife and cow – tend to be the first symptoms of A type of dementia known as Aplain Progressive Primary (app). Another sign is a subtle difficulty in committing phrases, highlighted by errors of verbal and nominal agreement never committed or inversion in the order of words, for example. Writing errors (dysgraphia) and reading difficulties (dyslexia) may also arise, so that writing and reading becomes tasks with progressive difficulties, as well as expressing ideas and thoughts.
Progressive primary aphasia is a neurodegenerative disease of rare and difficult diagnosis that initially affects language related problems, affects communication and evolves into more serious cognitive changes and can progress similarly to Alzheimer’s disease or other types of dementia.
The neurological diagnosis of this Demencial syndrome requires a complete analysis, which, in addition to language and communication problems, involves other cognitive functions.
Now, a study supported by Fapesp and published in Plos One Magazine He has shown that this condition can be detected in advance through a series of speech therapy tests known as the assessment of Toulouse of Montreal and linguistic battery (MTL-BR).
“The possibility of diagnosing in advance and more carefully is great news, because the treatment is first started, the slower tends to be the progression of the disease. First the rehabilitation, the more the possibility that the patient is able to maintain the communicative discourse, the word, the reading and the writing skills. Obviously we disintegrate Kar’s skills. Professor to the Logopedia Department Federal University of San Paolo (UNIFESP) and corresponding author of the article.
In the study, the researchers evaluated 87 individuals, 2 of which are diagnosed with progressive primary aphasia and 58 healthy, combined by age and degree of education.
“We compare the performance of the participants with and without the syndrome in a vast number of tasks that involve different linguistic elaborations. Consequently, we observe surprising differences in some tasks and, in this phase of the work, we can identify the most relevant tests among the 22 tasks that make up the MTL-Bt battery”, says Ortiz.
Since it is a very extensive and complete battery, says the researcher, the identification of the key tests can help simplify the evaluation, making preliminary detection faster and more convenient.
According to the results, the tasks in which patients with progressive primary aphasia performed worse MTL-BR were: direct interview, oral understanding of the sentences, oral narrative speech, written understanding of phrases, dictation, semantic verbal fluidity, text name in numbers, Numical, dictation, understanding of the written text and numerical calculation (mental and written).
Ortiz explains that the test battery was chosen as the object of study because it provides a large evaluation of oral understanding and production (speech) and written, as well as being the only valid test existing in Brazil for language disorders acquired of neurological origin.
The research now passes to a new phase, which aims to identify what the most important linguistic activities would be for the identification of each variant of the syndrome.
Variants
The partial or total loss of the ability to understand and express the spoken or written language has gained the spotlight in 2022, with the Diffusion of the aphasia painting by the Hollywood Bruce Willis actorwhich then evolved to Frontotemporal dementia. In the same year, Brazilian cartoonist Angeli has announced his professional removal due to the syndrome.
Progressive primary aphasia is a different condition from infesia, which can derive from Race (race)Cerebral tumors and head -onal trauma. The app is part of the set of diseases known as dementia, affects the front of the brain and is considered even more aggressive than Alzheimer’s disease.
Even so, there is difficulty in diagnosing the app, above all because the initial symptoms can be very similar to those of other demencial syndromes, although there is a much greater commitment than language than other cognitive domains. Another difficult factor is the heterogeneity of cases. “Despite the importance of language regarding the differential diagnosis of neurodegenerative diseases, there is still a lack of language evaluation tools for all types of dementia, including primary progressive aphasia,” he says.
To make the diagnosis even more difficult, there are four app subtypes. One of the variants is primary progressive aphasia or non -fluent agrammatic, marked by the alteration of the syntaxic structure of the phrases, difficulty in understanding complex phrases that can be accompanied by an apraxia framework of language, in which the patient makes language errors with motor planning faults.
Another variant is the primary semantic primary aphasia, characterized by the difficulty of understanding words due to semantic commitment, anomies and difficulties in reading and writing irregular words. Logo Peny Peny Primary Progressive APRIPGION is considered more similar to the dementia of Alzheimer’s disease and, in such cases, the patient has difficulty understanding long content and undertakes to swim and omissions of language sounds.
There is also the mixed or non -classifiable app, marked by linguistic changes in which a specific linguistic profile is not identified because patients do not have the characteristics envisaged for one of the variants or have characteristics of different variants, making it difficult for the specific diagnosis of one of them.
“And it is in this sense that our study contributes to the diagnosis, as it allows the changes in early identification of the language, highlighting the differences between primary progressive aphasia and the other Demencial syndromes,” says Ortiz.
Source: Terra
Ben Stock is a lifestyle journalist and author at Gossipify. He writes about topics such as health, wellness, travel, food and home decor. He provides practical advice and inspiration to improve well-being, keeps readers up to date with latest lifestyle news and trends, known for his engaging writing style, in-depth analysis and unique perspectives.
