The research is already one of the largest analyzes of autism spectrum disorder (ASD) and has been able to detect genetic components linked to the condition.
one of the largest studies ever conducted (to date) on autism spectrum disorder (ASD) was published in the scientific journal Genetics of nature in the last week of this month. The work, developed in collaboration with scientists and specialized databases, had more than 150,000 participants. Of these, 20,000 were diagnosed with ASD.
Through the genetic analysis of each patient, the researchers were able to identify 72 genes (DNA molecules responsible for traits that will be inherited at birth) associated with the disorderand another 250 components that would also be linked to the TEA.
” Some individuals with Autism Spectrum Disorder carry mutations rarely seen in the general population. So, we explored the genes disrupted by these variants, “informs the research. One of the study’s co-authors, Joseph D. Buxbaum, added:” We know that many genes, when transmitted by mutation, contribute to autism. In this study, we were able to bring together multiple mutation types to get a much richer sense of the genetic architecture involved in the disorder. “
Scientists have even found out ASD-related genes tend to be activated at an already mature stage of neurological formation of the child, while the molecules linked to developmental delay are activated at the beginning of the composition of neurons.
The research also found that genes strongly related to the disorder, such as the 72 already mentioned, may be correlated with others that increase the risk of schizophrenia. “These analyzes indicate that there are shared genetic risk factors between autism and other neurological and psychiatric disorders.”commented Professor Buxbaum.
For the co-author, the findings would facilitate an accurate approach to the follow-up of people with ASD. “Treatments that work for carriers of one mutation in one type of gene may not work for others with a different mutation. The more we advance in the objectives identified in the genetic analyzes, the greater the potential we will have to help, which could have a significant impact on the treatment of autism and developmental delay around the world, “he said.
Source: Terra
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