Scientists discover how to stimulate a receptor to rebuild bones and ultimately fight osteoporosis

Scientists discover how to stimulate a receptor to rebuild bones and ultimately fight osteoporosis


By activating a specific receptor it is possible to strengthen fragile bones and promote regeneration in an unprecedented way




A new study led by the University of Leipzig, Germany, in collaboration with Shandong University, China, has identified a cellular receptor called GPR133 that is essential for bone density. It works through bone-forming cells, known as osteoblasts, which are responsible for building and regenerating bone tissue, a process critical to maintaining bone health throughout life.

The discovery is relevant because osteoporosisone of the most common diseases in aging societies, it remains a major medical challenge. According to the declarationMillions of people, especially postmenopausal women, suffer bone loss and fractures that directly compromise their quality of life.

GPR133 and the potential for new treatments

The study, published in the journal Signal transduction and targeted therapyrevealed that the GPR133 receptor can be activated through chemical compounds, which paves the way for the development of new drug therapies with fewer side effects. Variations in GPR133 have previously been linked to bone density, which is why researchers focused their attention on the protein encoded by the gene.

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Source: Terra

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