The syndrome is characterized by the acute deterioration of two or more organs, which end up losing their function and leading to septic shock.
A Multiple Organ Failure Syndrome (MOFS)identified as the cause of death of former player and former coach Mario Jorge Lobo Zagallo92 years old, is characterized by the acute deterioration of two or more organs, which end up losing their function and leading to septic shock, according to the Ministry of Health.
The syndrome can also be triggered by polytrauma, extensive burns, lung contusions, snake bites and widespread infections. According to the Ministry, this has been one of the main causes of death in Brazil during the Covid-19 pandemic.
In the case of Zagallo, the former coach was admitted to the Barra D’Or hospital in Rio de Janeiro in August last year to treat a urinary infection that had worsened.
Again according to the Ministry, patients suffering from septic shock experience a sharp drop in blood pressure, reducing the oxygenation of the organs which end up progressively failing. The progressive degradation of organs leads to a functional imbalance that can become irreversible.
The organs generally affected are the lungs, kidneys, stomach and liver, but cardiac, brain, intestinal and glandular lesions can also occur, which alter immune and coagulation profiles.
Diagnosis is made by evaluating clinical symptoms and physical and laboratory test results that show, for example, a heart rate above 90 beats per minute and a significant increase or decrease in leukocytes (white blood cells) in the blood.
Due to the severity of multiorgan deterioration, the syndrome is linked to high morbidity and mortality. The mortality rate rises from 60% when two organs fail, to 85% when three organs fail, and up to 100% when four or more organs fail.
In Brazil, approximately 25% of patients admitted to intensive care units (ICU) have multiple organ failure. Interestingly, the first detailed description of the syndrome was published in 1974 by the Brazilian doctor Granville Garcia de Oliveira. For his work, Oliveira was nominated to receive the Nobel Prize in Medicine.
Source: Terra
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