The organoids were developed by centenary blood cells that are part of the project conducted to the center for studies on human genome and stem cells; The goal is to discover genes that protect the brain from the effects of age
At 116, Nun inah Canabarro Lucas is the oldest woman in the world, according to the Gerontology Research Group. Brazilian religious, who currently lives Porto Alegre (RS)hook chocolateshatred bananaHe directed a music band and traveled to all Latin America countries. In 2022, he contracted COVID-19 And surprisingly, he recovered without important complications.
Laura, 105, began to swim at 70 years old. Currently, it shows the agility of a young woman and excellent cognitive ability. Instead of losing muscle strength over time, as expected, the swimmer of Minas Gerais has preserved the muscles and started winning medals at 100.
Already Milton, from Brasilia, a veterinarian who at the age of 108 accompanied and commented on all the scientific progress reported, was able to appoint and remember the importance of all those present at his 107th birthday party – something unknowingly also for those who celebrate a couple of decades.
Everyone is part of a project conducted at the Center for Studies of Human Genome and Staminali (Cecgh -Cel) –a research, innovation and diffusion center based on Fapesp (Cepid) (Cepid) University of San Paolo (USP). The study is mapping the genetic code of healthy centenarians looking for gene decisive for this Exceptional longevity. So far 75 centenarians have been collected and the search for new volunteers continues.
“We want to identify the protective genes of common diseases a aginglike dementia and those related to muscle loss. We know that maintaining a healthy lifestyle is very important to obtain a quality of life. However, we also know that after 90 years, genetics is much more decisive than the environment, “says Mayana Zatz, Cecgh-Cel coordinator.
In addition to Collecting The Blood of Centenaries and Sequencing Their Genomes, Researchers are reprogramming Blood Cells (Erythroblasts) and Touring Them Intnced Plurripotent Stem Cells (IPS), Which Allaws Them to Differentiate Them in Any Other Types of Cells, Such As, Such as. as muscle, bone or nervous. This also allows the creation of organoids: mini -irrigans developed in the laboratory that can be used to study the functioning of body systems.
With the mini -brace obtained from the cells donated by the Brazilian centenaries, the researchers intend to study the genes related to the protection of neurodegenerative processes associated with Senis dementia, Alzheimer’s, Parkinson’s and other common aging diseases. But for this, in addition to moving monitoring and active research of healthy centenarians, they are also investing in the development of more complex mini. The protocols have developed so far have been described In one of the chapters of the book series Methods in molecular biologyPublished by the publisher Springer.
“We are working on two fronts. In the first place, we have cohort [grupo de voluntários do estudo] of the Brazilian centenaries. It is something that does not exist in the world, since they have a great genetic variability because of our Crocegenation. This can allow us to identify multiple protective genes. At the same time, we are developing more complex organoids, capable of imitating in a broader way what happens in brain of the Centenaries “, says Zatz.
This means developing organoids that, in addition to neurons, also have other types of central nervous system cells, such as micro, which recognize and report the presence of pathogens, as well as playing an important role in the development of the brain.
“With this complex and more sophisticated experimental model it is possible to replicate various aspects of brain functions, interactions and organization. It is an ideal model for studying both brain development and neurological disorders, since it imitates cellular architecture and physiological processes It imitates from brain man “, explains Raiane Ferreira, a researcher and doctorate of Fapesp Cach-Cel.
“We are not developing anything new, advancing only in the creation technique of mini -more complex colors that allow us, for example, to include the micoglia,” underlines Ferreira.
From start to finish
According to the researcher, there is a complication in this process: IPS cells – the basis for the production of laboratory organoids – have more embryonic characteristics and mini -cervelli are commonly used for the study of neurosviluppo.
“Our challenge is to be able to adapt the model to express stress factors present in aging. So we can study how neuro -gag occurs,” he says.
“The participants in the project are all very lucid. We know that the micoglia has a very important function in relation to Alzheimer and other dementia due to its role in homeostasis [equilÃbrio] of the brain in aging. Therefore, we try to understand in this phase of research if the micoglia of these elderly would also be different, suffering from less aging effects. This will only be possible to discover from the organoids that we are developing, “says Ferreira.
Source: Terra
Ben Stock is a lifestyle journalist and author at Gossipify. He writes about topics such as health, wellness, travel, food and home decor. He provides practical advice and inspiration to improve well-being, keeps readers up to date with latest lifestyle news and trends, known for his engaging writing style, in-depth analysis and unique perspectives.
