The study showed a relationship between a few hours of sleep and the emergence of biomarkers associated with Alzheimer’s
A study by the research center of the Pasqual Maragall Foundation, the Barcelonaβeta Brain Research Center (BBRC), in collaboration with researchers from the University of Bristol, revealed that poor sleep and poor quality rest are associated with an increased chance of be healthy. That is, even without any cognitive impairment the risk increases.
The team used data from the largest cohort to date, the Alzheimer’s Dementia Prevention Longitudinal Cohort Study (EPAD LCS). With this, the researchers were able to validate the hypothesis that sleep deprivation is associated with cerebrospinal fluid (CSF) biomarkers. This, in turn, predicts an increased future chance of developing the disease in people who do not have symptoms of dementia.
I study
The team analyzed data from 1,168 adults over the age of 50. Cross-sectional analyzes revealed that poor sleep quality is significantly associated with increased CSF t-tau protein. Among other findings, a short sleep duration of less than seven hours per night has been shown to correlate with higher p-tau and t-tau values, key biomarkers for measuring Alzheimer’s risk in the preclinical stage of the disease. .
“Our findings further strengthen the hypothesis that sleep disruption may represent a risk factor for Alzheimer’s disease. For this reason, future research is needed to test the effectiveness of preventive practices. are designed to improve sleep in the presymptomatic stages of the disease in order to reduce the pathology of Alzheimer’s disease, ”said Laura Stankeviciute, a pre-doctoral researcher at the BBRC and one of the lead authors of the study.
Sleep abnormalities are common in Alzheimer’s disease. Sleep quality may decline early in the preclinical stage of the disease, even when there are no other symptoms. Understanding how and when sleep deprivation contributes to the progression of Alzheimer’s disease is important for the design and implementation of future therapies. This demonstrates the relevance of the study.
“Epidemiological and experimental data available to date already suggest that sleep abnormalities contribute to the risk of Alzheimer’s disease. However, previous studies had limitations due to the lack of disease biomarkers. sample size of participants, ”says Stankeviciute, who adds that this is the first study to include all of these factors.
importance of sleep
According to neurologist at the Israeli Hospital Albert Einstein, sleep has always been refreshing for the human brain. “The less we sleep, the more brain damage can occur,” he says. He points out that the risk is even greater for young people, as unrefreshing sleep prevents brain maturation, which usually occurs until the age of 25. The consequences appear only in the late stage of life.
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Source: Terra

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